Using a unique mechanism of action that combines percussion, entrainment, and high-velocity flow, Sentec Intrapulmonary Percussive Ventilation therapy can make a big impact for respiratory patients – improving gas exchange capacity through the resolution of secretion retention, atelectasis, and hyperinflation & air trapping.

Along with IPV therapy’s clinical results in treating patients with respiratory complications, it has a demonstrated history of being safe and well-tolerated across diverse patient populations, care settings, and delivery interfaces.

IPV Therapy is safe in patients with neuromuscular diseases. According to one study below, patients themselves even reported that they were satisfied with the treatment.

“IPV is a safe airway clearance method for tracheostomized Duchenne muscular dystrophy patients, and this preliminary study suggests that IPV increases the effectiveness of assisted mucus clearance techniques.”

• Study Title: Effect of Intrapulmonary Percussive Ventilation on Mucus Clearance in Duchenne Muscular Dystrophy Patients: A Preliminary Report
• Population: Patients with DMD who required long-term ventilation (>18/24 hr. per day)
• Citation: Toussaint, M., et al. Respir Care. 2003.

“Our results are consistent with those of previous pilot studies demonstrating safety of IPV. No serious adverse effects occurred related to use of IPV…”

“Patient satisfaction with IPV treatments was favorable, as assessed by questionnaire, with patients indicating ability to remain sitting in their wheelchairs during IPV as the main advantage of IPV compared with chest physiotherapy and postural drainage.”

• Study Title: Intrapulmonary percussive ventilation vs. incentive spirometry for children with neuromuscular disease
• Population: Children with impaired pulmonary function resulting from NMD
• Citation: Reardon, C.C., et al. Arch Pediatr Adolesc Med. 2005.

IPV Therapy is safe in patients with respiratory diseases like chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF). Participants even reported that the therapy was “relatively comfortable.”

“Indeed, [IPV] is safe, and overall well tolerated.”

• Study Title: Physiological response to intrapulmonary percussive ventilation in stable COPD patients
• Population: Adult patients with COPD
• Citation: Nava, S., et al. Respir Med. 2006.

“IPV is a safe technique and may prevent further deterioration in patients with acute exacerbations of COPD with mild respiratory acidosis.”

• Study Title: Intrapulmonary percussive ventilation in acute exacerbations of COPD patients with mild respiratory acidosis: a randomized controlled trial
• Population: Adults hospitalized in the ICU with an acute COPD exacerbation
• Citation: Vargas, F., et al. Crit Care. 2005.

“The IPV is a [safe] non-pharmacologic airway clearance therapy that can be used on patients with different sorts of respiratory diseases…”

“In patients with bronchiectasis and productive cough, the short-term IPV was described as safe and effective as the CPT, and it was defined as a more comfortable airway cleaning therapy.”

• Study Title: Efficacy of short-term intrapulmonary percussive ventilation in patients with chronic obstructive pulmonary disease
• Population: Adult patients with COPD
• Citation: Testa, A., et al. Disabil Rehabil. 2015.

“Participants tolerated all respiratory treatment without adverse consequences. Subjectively, participants reported no discomfort with use of IPV compared with conventional P&PD therapy.”

• Study Title: Comparison of Intrapulmonary Percussive Ventilation and Chest Physiotherapy: A Pilot Study in Patients With Cystic Fibrosis
• Population: Patients with cystic fibrosis
• Citation: Natale, J.E., et al. Chest. 1994.

“After completion of the trial, they surveyed the 8 members of the IPV group regarding frequency of therapy, time spent on therapy, reliance on others, and comfort of IPV. In general, the participants thought they performed more bronchopulmonary hygiene with IPV, spent less time on therapy, relied less on others for therapy, and thought IPV was relatively comfortable. All 8 participants completing the survey said they would continue to use IPV if given the opportunity..”

• Study Title: A comparison of the therapeutic effectiveness of and preference for postural drainage and percussion, intrapulmonary percussive ventilation, and high-frequency chest wall compression in hospitalized cystic fibrosis patients
• Population: Patients with cystic fibrosis, hospitalized for an acute exacerbation of pulmonary symptoms
• Citation: Varekojis, S.M., et al. Respir Care. 2003.

IPV therapy is designed to support patients regardless of ventilation strategy or level of respiratory compromise. It can be used in-line with a ventilator or as a standalone therapy. To read more about the impact Sentec IPV Therapy could have for your patients, download the Clinical Impact Summary.